Erratum: Corrigendum: Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia
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چکیده
منابع مشابه
Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.
Expansion of GAA x TTC triplets within an intron in FXN (the gene encoding frataxin) leads to transcription silencing, forming the molecular basis for the neurodegenerative disease Friedreich's ataxia. Gene silencing at expanded FXN alleles is accompanied by hypoacetylation of histones H3 and H4 and trimethylation of histone H3 at Lys9, observations that are consistent with a heterochromatin-me...
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Friedreich ataxia, the most prevalent inherited ataxia, is caused by an expanded GAA triplet-repeat sequence in intron 1 of the FXN gene. Repressive chromatin spreads from the expanded GAA triplet-repeat sequence to cause epigenetic silencing of the FXN promoter via altered nucleosomal positioning and reduced chromatin accessibility. Indeed, deficient transcriptional initiation is the predomina...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2007
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio0707-432